Constipation is a widespread condition that impacts quality of life1

Constipation symptoms can interrupt patients’ daily lives1
~70% of people had difficulty working, and at least 1 in 10 people missed work or school completely due to chronic constipation.
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References: 1. Johanson JF, Kralstein J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther. 2007;25:599-608. doi:10.1111/j.1365-2036.2006.03238.x 2. NIH. National Institute of Diabetes and Digestive and Kidney Diseases. Definitions & facts for constipation. Accessed December 5, 2022. https://www.niddk.nih.gov/health-information/digestive-diseases/constipation/definition-facts 3. McCrea GL, Miaskowski C, Stotts NA, Macera L, Varma MG. A review of the literature on gender and age differences in the prevalence and characteristics of constipation in North America. J Pain Symptom Manage. 2009;37(4):737-745. doi:10.1016/ j.jpainsymman.2008.04.016 4. Vlitos A, Davies GJ. Bowel function, food intake and the menstrual cycle. 1996;9(1):111-134. doi:10.1079/NRR19960008 5. NIH. Office of Dietary Supplements. Iron. Fact sheet for health professionals. Accessed December 5, 2022. https://ods.od.nih.gov/factsheets/iron-HealthProfessional/ 6. Bradley CS, Kennedy CM, Turcea AM, Rao SSC, Nygaard IE. Constipation in pregnancy: prevalence, symptoms, and risk factors. Obstet Gynecol. 2007;110(6):1351-1357. doi: 10.1097/01.AOG.0000295723.94624.b1 7. Gjerdingen DK, Froberg DG, Chaloner KM,McGovern PM. Changes in women’s physical health during the first postpartum year. Arch Fam Med. 1993;2(3):277-283. doi:10.1001/archfami.2.3.277 8. Oliveira SC, Pinto-Neto AM, Conde DM, et al. Constipation in postmenopausal women. Article in Portuguese. Rev Assoc Med Bras. 2005;51(6):334-341. 9. Mayo Clinic. Constipation. Accessed December 5, 2022. https://www.mayoclinic.org/diseases-conditions/constipation/symptoms-causes/syc-20354253
Diagnostic tools: Distinguishing occasional vs chronic constipation
The criteria below may help when diagnosing patients1,2
While there’s no formal definition for occasional constipation, it can include1:
- Infrequent bowel movements
- Difficulty in passing stool
- Straining
- The feeling of incomplete evacuation
Chronic constipation is defined by Rome III criteria2:
- Presence of 2 or more of the following symptoms:
- Straining during ≥25% of defecations
- Lumpy or hard stools in ≥25% of defecations
- Sensation of incomplete evacuation for ≥25% of defecations
- Sensation of anorectal obstruction/blockage for ≥25% of defecations
- Manual maneuvers to facilitate ≥25% of defecations (such as digital evacuation, support of the pelvic floor)
- Fewer than 3 bowel movements a week
- Loose stools are rarely present without the use of laxatives
- Criteria must have been met for the previous 3 months with symptom onset at least 6 months prior to diagnosis
The Bristol scale describes changes in bowel movement consistency3
The Bristol scale can be used to evaluate bowel movements and helps patients describe them in an objective and minimally embarrassing manner.
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References: 1. Bharucha AE, Dorn SD, Lembo A, Pressman A. American Gastroenterological Association medical position statement on constipation. Gastroenterology. 2013;144(1):211-217. doi:10.1053/j.gastro.2012.10.029 2. Ford AC, Moayyedi P, Lacy BE, et al. American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gasteroenterol. 2014;109(Suppl 1):S2-S26. 3. Lewis SJ, Heaton KW. Stool form scale as useful guide to intestinal transit time. Scand J Gastroenterol. 1997;32(9):920-924. doi: 10.3109/00365529709011203
Comparison of OTC occasional constipation treatments
OTC laxatives work in different ways
Click for more details about each treatment >
The trademarks depicted herein are owned by their respective owners.
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References: 1. Hammer HF, Santa Ana CA, Schiller LR, Fordtran JS. Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose. J Clin Invest. 1989;84(4):1056-1062. doi:10.1172/ JCI114267 2. Andrews CN, Storr M. The pathophysiology of chronic constipation. Can J Gastroenterol. 2011;25(Suppl B):16B-21B. 3. DiPalma JA, DeRidder PH, Orlando RC, et al. A randomized, placebo-controlled, multicenter study of the safety and efficacy of a new polyethylene glycol laxative. Am J Gastroenterol. 2000;95(2):446-450. doi:10.1111/j.1572-0241.2000.01765.x 4. DiPalma JA, Cleveland MB, McGowan J, Herrera JL. A comparison of polyethylene glycol laxative and placebo for relief of constipation from constipating medications. South Med J. 2007;100(11):1085-1090. doi:10.1097/SMJ.0b013e318157ec8f 5. Fiorini K, Sato S, Schlachta CM, Alkhamesi NA. A comparative review of common laxatives in the treatment of constipation. Minerva Chir. 2017;72(3):265-273. doi:10.23736/S0026-4733.17.07236-4
Not all OTC constipation treatments offer both effective results and few side effects
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BRAND1
MiraLAX®
HOW IT WORKS2-4
- Works naturally by attracting water in the colon to ease, hydrate, and soften stool to relieve constipation
- Generally produces a bowel movement in 1 to 3 days
INDICATION1
- Occasional constipation
CONSIDERATIONS5
- Works without causing harsh side effects such as gas, bloating, cramping, and sudden urgency
- Proven safe in patients, including the elderly
- No known clinically relevant drug-to-drug interactions
- Patients should not use if they have kidney disease, except under the advice and supervision of a doctor
BRAND6:
Phillips'® Milk of Magnesia
HOW IT WORKS6,7:
- Draws water into the intestine to produce a bowel movement
- Usually produces a bowel movement in 30 minutes to 6 hours
INDICATION6:
- Occasional constipation
CONSIDERATIONS6,7:
- Patients with kidney disease, a magnesium-restricted diet, or taking prescription drugs need to consult a doctor before use
BRAND8-10:
Dulcolax® (bisacodyl), ex-lax® and Senokot® (sennosides)
HOW IT WORKS7-10:
- Bisacodyl and sennosides stimulate the walls of the intestine, causing the muscles to contract and clear the bowel
- Generally produces a bowel movement in 6 to 12 hours
INDICATION7-10:
- Occasional constipation
CONSIDERATIONS8-10:
- Do not use bisacodyl within 1 hour after taking an antacid or milk
- Sennosides may affect how other drugs work and should be taken 2 hours before or after other drugs
BRAND12:
Metamucil®
HOW IT WORKS7,13:
- Softens and increases the bulk of digested food, making it easier for waste to travel through and leave the body
- Generally produces an effect in 12 to 72 hours
INDICATION12:
- Occasional constipation
CONSIDERATIONS7,12:
- Can ferment in the intestine, which may cause gas and bloating
- May affect how well other medicines work and should be taken at least 2 hours before or after prescribed medication
BRAND14,15:
Colace®, Phillips'® Stool Softener
HOW IT WORKS7,14:
- Allows water and fats to get into the stool. This helps soften fecal material and makes defecation easier
- Generally produces an effect in 12 to 72 hours
INDICATION14,15:
- Occasional constipation
CONSIDERATIONS7:
- Does not force passing of bowel movements
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References: 1. MiraLAX® Drug Facts, Bayer Healthcare.2. Andrews CN, Storr M. The pathophysiology of chronic constipation. Can J Gastroenterol. 2011;25(Suppl B):16B-21B. 3. Schiller LR, Emmett M, Santa Ana CA, Fordtran JS. Osmotic effects of polyethylene glycol. Gastroenterology. 1988;94(4):933-941. doi:10.1016/0016-5085(88)90550-1 4. Hammer HF, Santa Ana CA, Schiller LR, Fordtran JS. Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose. J Clin Invest. 1989;84(4):1056-1062. doi:10.1172/JCI114267 5. DiPalma JA, DeRidder PH, Orlando RC, et al. A randomized, placebo-controlled, multicenter study of the safety and efficacy of a new polyethylene glycol laxative. Am J Gastroenterol. 2000;95(2):446-450. doi:10.1111/j.1572-0241.2000.01765.x 6. Phillips® Milk of Magnesia Drug Facts. Bayer Consumer Health. 7. Fiorini K, Sato S, Schlachta CM, Alkhamesi NA. A comparative review of common laxatives in the treatment of constipation. Minerva Chir. 2017;72(3):265-273. doi:10.23736/S0026-4733.17.07236-4 8. Dulcolax® Laxative Tablets Drugs Facts. Chattem, Inc. 9. ex-lax® Regular Strength Drug Facts. GSK. 10. Senokot (sennosides) Drug Summary. Accessed December 5, 2022. https://pdr.net/drug-summary/Senokot-sennosides-3182.84 11. Dulcolax. December 5, 2022. https://www.drugs.com/dulcolax.html 12. Metamucil Psyllium Fiber Supplement. Accessed December 5, 2022. https://www.metamucil.com/en-us/products/fiber-powders/sugar-free- orange-smooth 13. Metamucil FAQs. Accessed December 5, 2022. https://www.metamucil.com/en-us/faqs/metamucil-faqs 14. Colace® Regular Strength Product Information. Accessed December 5, 2022. https:// www.colacecapsules.com/products/colace-regular-strength/ 15. Phillips® Stool Softener Liquid Gels Drug Facts. Bayer Consumer Health.
The trademarks depicted herein are owned by their respective owners.
Medications that may cause constipation
Many commonly used medications have constipation as a side effect. Depending on patients' existing medical concerns, some current treatment regimens may be the cause of their constipation symptoms
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PRIMARY USE |
Relieve heartburn |
ACTIVE INGREDIENT |
Aluminium hydroxide |
PRIMARY USE |
Control epilepsy and other seizure disorders |
ACTIVE INGREDIENT |
Divalproex sodium |
PRIMARY USE |
Lower blood pressure |
ACTIVE INGREDIENT |
Clonidine |
PRIMARY USE |
Relieve symptoms of Parkinson’s disease |
ACTIVE INGREDIENT |
Levodopa, carbidopa |
PRIMARY USE |
Treat symptoms of psychosis |
ACTIVE INGREDIENT |
Haloperidol, clozapine, risperidone |
PRIMARY USE |
Decrease intestinal cramps, control overactive bladder |
ACTIVE INGREDIENT |
Dicyclomine hydrochloride, oxybutynin chloride, tolterodine tartrate |
PRIMARY USE |
Reduce cholesterol |
ACTIVE INGREDIENT |
Colestipol hydrochloride |
PRIMARY USE |
Treat cancer |
ACTIVE INGREDIENT |
Pemetrexed disodium, carboplatin |
PRIMARY USE |
Lower blood pressure, promote excretion of water |
ACTIVE INGREDIENT |
Furosemide, spironolactone, hydrochlorothiazide, triamterene |
PRIMARY USE |
Iron deficiency anemia |
ACTIVE INGREDIENT |
Ferrous sulfate |
PRIMARY USE |
Relieve pain |
ACTIVE INGREDIENT |
Morphine sulfate, codeine phosphate, oxycodone hydrochloride |
This represents a small sample of brand name products, some of which may no longer be available. The trademarks depicted in this table are the property of their respective owners.
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References: 1. Aluminum hydroxide; magnesium hydroxide; simethicone. Accessed December 5, 2022. https://my.clevelandclinic.org/health/drugs/19931-aluminum-hydroxide-magnesium-hydroxide-simethicone-oral-suspension 2. Gaviscon® Tablets. Accessed December 5, 2022. https://www.gaviscon.com/products/tablets.html 3. Depakote®. Prescribing information. Abbvie Inc.; 2021. 4. Catapres-TTS®. Prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc.; 2011. 5. Rytary. Prescribing information. Amneal Pharmaceuticals LLC; 2019. 6. Haldol®. Package insert. Ortho-McNeil Pharmaceutical, Inc.; 2009. 7. Clozaril®. Prescribing information. Novartis Pharmaceuticals Corporation; 2020. 8. Risperdal® Consta®. Prescribing information. Ortho-McNeil-Janssen Pharmaceuticals, Inc.; 2010. 9. Bentyl®. Prescribing Information. Axcan Pharma US, Inc.; 2011. 10. Ditropan XL®. Prescribing information. Janssen Pharmaceuticals, Inc.; 2016. 11. Detrol® LA. Prescribing information. Pharmacia & Upjohn Company; 2018. 12. Colestid®. Package insert. Pharmacia & Upjohn Company; 2017. 13. Alimta. Prescribing information. Eli Lilly and Company; 2004. 14. Paraplatin®. Package insert. Bristol-Myers Squibb Company; 2010. 15. Furosemide. Package insert. Hospira, Inc.; 2016. 16. Aldactazide®. Package insert. G.D. Searle; 2014. 17. Dyazide. Prescribing information. GlaxoSmithKline; 2020. 18. Slow Fe® Drug Facts. GSK. 19. MS Contin®. Prescribing information. Purdue Pharma L.P.; 2016. 20. Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate. Prescribing information. Teva Pharmaceuticals USA, Inc.; 2019. 21. Percocet®. Package insert. Par Pharmaceutical; 2020. 22. OxyContin®. Prescribing information. Purdue Pharma L.P.; 2018